Author : Peter Nicholls (auth.), Sergio Papa, Ferruccio Guerrieri, Joseph M. Tager (eds.)
Description:The book covers major advances made in cellular bioenergetics, a central topic in biological and medical research. The chapters, contributed by authors representing major groups working in the field, extend from the latest advancements in X-ray crystallographic analysis of the atomic structure of energy transfer membrane proteins and analysis of their mechanism of action, to perspectives on the implication of their genetic and phenotypic defects in human diseases. The book, intended for researchers, clinicians and students aims at providing an up-to-date appraisal of this rapidly developing biomedical field. The book consists of thirty-one chapters contributed by leading experts in the field of cellular bioenergetics. Three sections cover the X-ray crystallographic analysis, mutational analysis and mechanism of action of mitochondrial and prokaryotic respiratory enzymes, ATP synthase and mitochondrial carriers. One section deals with genetics and biogenesis of mitochondria. The fourth section covers genetic and phenotypic defects in mitochondrial energy transfer proteins associated with inborn and/or degenerative human diseases and aging.