SpringerBriefs in Biochemistry and Molecular BiologyUntranslated Gene Regions and Other Non-coding Elements: Regulation of Eukaryotic Gene Expression [1ed.]3034806787, 9783034806787

Author : Lucy W. Barrett, Sue Fletcher, Steve D. Wilton (auth.)
Description:There is now compelling evidence that the complexity of higher organisms correlates with the relative amount of non-coding RNA rather than the number of protein-coding genes. Previously dismissed as junk DNA, it is the non-coding regions of the genome that are responsible for regulation, facilitating complex temporal and spatial gene expression through the combinatorial effect of numerous mechanisms and interactions working together to fine-tune gene expression. The major regions involved in regulation of a particular gene are the 5 and 3 untranslated regions and introns. In addition, pervasive transcription of complex genomes produces a variety of non-coding transcripts that interact with these regions and contribute to regulation. This book discusses recent insights into the regulatory roles of the untranslated gene regions and non-coding RNAs in the control of complex gene expression, as well as the implications of this in terms of organism complexity and evolution.
Categories: Biology Molecular
Year :2013
Publisher : Springer Basel
Language : English
N° Of Pages : 56[65]
File Info : pdf 2 Mb